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論文內容
論文分類碩士論文
學號10165605
姓名沈婉琳
標題(中)新作用機制殺蟲劑對白線斑蚊（Aedes albopictus）幼蟲之藥效及其抗藥性之研究
標題(英)The toxic effect of novel insecticides to mosquito (Aedes albopictus) and its resistance
指導教授王順成
畢業日期2014-08
附件檔案 
參考連結http://ndltd.ncl.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dnclcdr&s=id=%22102CYUT0087008%22.&searchmode=basic&extralimit=asc=%22%E6%9C%9D%E9%99%BD%E7%A7%91%E6%8A%80%E5%A4%A7%E5%AD%B8%22&extralimitunit=%E6%9C%9D%E9%99%BD%E7%A7%91%E6%8A%80%E5%A4%A7%E5%AD%B8
摘要白線斑蚊(Aedes albopictus)為傳播登革熱重要病媒蚊之一。本研究針對八種不同作用機制之殺蟲劑，評估其對抗、感品系白線斑蚊幼蟲之藥效，以瞭解舊型藥劑之藥性及誘發抗藥性發生情形及新型藥劑未來使用之潛力，同時利用白線斑蚊藥效測試結果與國內外往昔研究比較，以瞭解白線斑蚊在國內、外對常用殺蟲劑抗藥性發展之特異性，文中另比較白線斑蚊與另一重要之登革熱病媒蚊-埃及斑蚊(Aedes aegypti)對相同測試藥劑之藥效及抗藥性，分析種間對藥劑之差異性。研究結果顯示2013年白線斑蚊對除蟲菊類之Deltame
參考文獻王正雄、黃基森、賴建榮，「屏東縣琉球鄉應用魚類生物防治登革熱病媒蚊初步試驗報告」，高雄醫誌第六卷，第七期，第382-388頁(1990)。王正雄，「蓋斑鬥魚防治登革熱病媒埃及斑蚊幼蟲潛力之研究」。中華衛誌，第十七卷，第六期，第458-467頁(1998)。王正雄，「對環境友善安全的微生物殺蟲劑--蘇力菌」，環境檢驗，第四十九卷，第10-17頁(2003)。行政院衛生福利部疾病管制署，「登革熱防治工作指引」，行政院衛生福利部疾病管制署編，台北(2012)。行政院衛生福利部疾病管制署統計資料，http://nidss.cdc.gov.tw/singledisease.aspx?pt=s&dc=1&dt=2&disease=061&treeid=1f07e8862ba550cf&nowtreeid=e7bbb22a47416adc，(2014)。行政院環境保護署，「環境用藥許可證及病媒防治業網路查詢系統」，(http://mdc.epa.gov.tw/MDC/search/search_License.aspx)，(2014)。吳盈昌，「1981屏東縣琉球鄉之第二型登革熱流行」，中華微免雜誌，第十九卷，第203-211頁(1986)。吳鳳敏、劉冠顯、鐘佳容，「由登革熱防治政策探討民國87年冬季台灣南部登革熱病例爆增之原因」，院內感染控制雜誌，第十期，第三卷，第219-227頁(2000)。吳旺宗，「新作用機制殺蟲劑對埃及斑蚊(Aedes aegypti)幼蟲抗藥性之研究」，碩士論文，朝陽科技大學環境工程與管理系，台中(2014)。李學進，「白線斑蚊卵、幼蟲及蛹之發育」，中華昆蟲，第十四卷，第13-32頁(1994 a)。李學進，「白線斑蚊之吸血、產卵與壽命」，中華昆蟲，第十四卷，第217-231頁(1994 b)。李學進，「登革熱病媒蚊之孳生源清除及防治宣導」，第十屆病媒防治技術研討會論文集，高雄醫誌，第十四卷，第74-89頁(1998)。周欽賢、連日清、王正雄，「醫學昆蟲學」（修訂第二版），國立編譯館主編，台北南山堂出版社，第43-60;79-109;163-174頁(1988)。林鼎翔、呂良振、徐明輝、林巧、王錫杰，「高雄市鼓山區野生臺灣彌猴棲息地蚊類感染登革熱病毒之研究」，疫情報導，第九卷，第11期，第223-228頁(1993)。林鶯熹，「水深、水溫及幼蟲飼料對埃及斑蚊和白線斑蚊產卵的影響」，碩士論文，國立中興大學昆蟲學系研究所，台中(1994)。林鶯熹、陳靜宜、徐爾烈，「蚊蟲抗藥性及應對策略」，第九屆病媒防治技術研討會論文集，第101-109頁(1997)。林鶯熹、吳淑靜、徐爾烈、鄧華真、何兆美、白秀華，「2002年台灣登革熱流行區埃及斑蚊的抗藥性」，台灣昆蟲，第二十三卷，第263-274頁(2003)。林鶯熹、吳懷慧、徐爾烈、張念台、羅怡佩，「台灣南部地區埃及斑蚊及白線斑蚊幼蟲對殺蟲劑的抗藥性」，台灣昆蟲，第三十二卷，第107-121頁(2012)。林俊宏，「登革熱流行因子與病媒蚊擴散模型之研究－兼論預警資訊系統之建構」，碩士論文，大同大學資訊經營研究所，台北(2005)。周欽賢、王正雄，「醫學昆蟲與病媒防制」，南山堂出版社，台北市。658頁(2002)。徐文秀，「登革熱病媒蚊白線斑蚊(aedes albopictus)防治藥劑之開發與應用」，碩士論文，朝陽科技大學環境工程與管理系，台中(2009)。徐爾烈，「台灣重要蚊蟲之發生及其抗藥性之研究」，行政院環保署，28頁(1988)。徐爾烈、李學進、陳錦生、張念台，「登革熱主要病媒蚊之發生密度調查」，行政院環保署，41頁(1990)。徐爾烈，「台灣地區登革熱病媒蚊抗藥性現況」，登革熱防治工作檢討會(97-3-13，2008)。夏維泰，「病媒防治噴藥器材」，環境用藥及病媒防治技術研討會論文集，第107-120頁(2006)。夏維泰、林秀品，「登革熱病媒蚊抗藥性監測研究(第二年)」，行政院衛生署疾病管制局101年度科技研究發展計畫(DOH101-DC-2303)，123 頁(2012)。張念台、梁龍文、吳懷慧，「屏東縣琉球鄉居民對登革熱及其病媒之認知」。中華昆蟲，第十五卷，第125-135頁(1995)。張念台，「屏東地區登革熱病媒蚊抗藥性及藥效評估」，行政院衛生福利部疾病管制署九十二年度科技研究發展計畫(DOH92-DC-1108)，22頁(2003)。張倫賢，「低溫對台灣地區埃及斑蚊與白線斑蚊幼蟲存活的影響」，碩士論文，國立臺灣大學昆蟲學研究所，台北 (2005)。張應闊、司袁仁、閻丙申，「衛生殺蟲劑復配的選擇及應用」，醫學動物防制，第十九卷，第九期，第516-520頁(2003)。張麗卿，「優質保養品選擇策略」，聯經出版社，250頁(2003)。陳健民，「環境毒物學」，新文京開發出版有限公司，臺北縣，第168-181頁(2007)。黃正中，「溫度對埃及斑蚊與白線斑蚊幼蟲發育之影響及其成蟲族群介量與產卵行為之觀察」，碩士論文，東海大學生物學系研究所，台中(1986)。黃旌集，「溫度與簇蟲對白線斑蚊與埃及斑蚊分佈的影響」，碩士論文，東海大學生物學系研究所，台中(1996)。黃基森，「臺彎地區斑蚊生態及其與登革熱流行之關係」，中華昆蟲特刊，第六號，第105-127頁(1991)。黃基森、徐爾烈，「高雄市登革熱病媒分布及孳生環境調查」，中華昆蟲，第十四卷，第233-244頁(1994)。黃基森、吳懷慧、張念台，「高雄市三民區斑蚊孳生環境之調查與登革熱流行原因之探討」，中華昆蟲，第十五卷，第215-225頁(1995)。黃志傑、李翠瓊、吳炳輝，「2004台灣地區登革熱疫情防治報告」，登革熱戰役實錄，第20-34頁(2004)。鄧華真，「登革熱病媒蚊藥效試驗及緊急噴藥標準作業規範」，行政院衛生衛生署疾病管制局九十二年度自行研究發展計畫(DOH92-DC-2036)，22頁(2003)。楊益昇，「登革熱發生流行風險及相關因子之探討」，碩士論文，國立屏東科技大學，屏東(2008)。曾朝豐，「登革熱病媒蚊綜合防治研究」，碩士論文，國立高雄大學運動健康與休閒學系，高雄(2012)。曾經洲，「昆蟲的穿腸毒藥蘇力菌」，行政院農業委員會農業藥物毒物試驗所科學發展，第三百九十一期，第7-9頁(2005)。路光輝、侯豐男，「細菌性病原菌防治蚊蟲之應用」，高雄醫誌，第六卷，第344-349頁(1990)。葛應欽，「登革熱流行病學－登革熱在台灣的流行」，高雄醫學科學雜誌，第五卷，第 1-11頁(1989)。潘銘正、劉振軒、張世忠，「媒介重要人畜傳染病的有害生物節肢動物篇」，行政院農業委員會動植物防疫檢疫局，台北市，第67-72；219頁(2007)。蕭文真，「都市地區埃及斑蚊與白線斑蚊產卵誘引調查」，碩士論文，國立中興大學昆蟲學系研究所，台中(2000)。謝再添。「殺蟲劑化學分類及其特性」。台中市，行政院農委會農業藥物藥毒試驗所。（2004）。羅怡珮、徐爾烈，「蚊類抗藥性現況」，第一屆病媒防治技術研討會，第145-160頁(1989)。羅怡珮，「臺灣白線斑紋抗藥性之研究」，博士論文，國立臺灣大學植物病蟲害學研究所，台北(1992)。鐘兆麟，「漫談登革熱防治」，行政院衛生署疫情報導，第二十二卷，第九期，第589-595頁(2006)。英文部分Apperson, C. S., and Georghiou, G. P.,“ Mechanisms of resistance to organophosphorus insecticides in Culex tarsalis,” J. Econ. Entomol., Vol. 68, No. 2, pp. 153-157 (1975).Bariami, V., Jones, C.M., Poupardin, R., Vontas, J., and Ranson, H.,“Gene amplification, ABC transporters and cytochrome P450s: unraveling the molecular basis of pyrethroid resistance in the dengue vector, Aedes aegypti, ” PLoS Negl Trop Dis., Vol. 6, No. 6, e1692(2012).Brengues, C., Hawkes, N. J., Chandre, F., McCarroll, L., Duchon, S., Guillet, P., Manguin, S., Morgen, J. C., and Hemingway, J., “Pyrethroid and DDT cross-resistance in Aedes aegypti is correlated with novel mutation in the voltage-gated sodium channel gene,” Med. Vet. Entomol., Vol. 17, pp. 87-94 (2003).Brown, A. W. A., “Insecticide resistance in mosquitoes a pragmatic review, ” J. Am. Mosq. Control Assoc., Vol. 2, pp.123-139 (1986).Brown, M.D., Carter, J., Watson, T.M., Thomas, P., Santaguliana, G., Purdie, D.M., and Kay, B.H., “ Evaluation of liquid Bacillus thuringiensis var. israelensi products for control of Australian Aedes arbovirus vectors, ” J. Am. Mosq. Control Assoc., Vol.17, No.1, pp.8-12 (2001).Bui-De Xue and Donald R., “Barnard. Boric acid bait kills adult mosquitoes (Diptera: Culicidae)”, J. Med. Entomol. Vol. 96, pp. 1559-1562(2003).Chadee, D. D., Williams, F. L. R., and Kitron, U. D., “ Impact of vector control on a dengue fever outbreak in Trinidad, West Indies, in 1998. Trop”, Med. Int. Health. Vol. 10, pp. 748-754(2005).Chan, K. L., “Singapores dengue haemorrhagic fever control programme: a Case study on the successful control Aedes aegypti and Aedes albopictus using mainly environment measuresas a part of integrate vector control”, SEAMIC Publication N0. 45. SEAMIC, Tokyo(1985).Chang, L. H., Hsu, E. L., Teng, H. J., and Ho, C. M., “Differential survival of Aedes aegypti and Aedes albopictus (Diptera: Culicidae) larvae exposed to low temperatures in Taiwan”, J. Med. Entomol. Vol. 44, pp. 205-210(2007).Crow, J. F. “Genetics of insect resistance to chemicals”, Ann. Rev. Entomol. Vol. 2, pp. 227-246(1957).Darriet, F., and V. Corbel. “ Laboratory evaluation of pyriproxyfen and spinosad, alone and in combination,against Aedes aegypti larvae. ” J. Med. Entomol.43: 1190-1194. (2006).Del Rosario, A., “Studies on the biology of Philippine mosquitoes. I. Some bionomic features of Aedes aegypti”, Philippine J. Sci. Vol. 90, pp. 361-370(1961).Del Rosario, A., “Studies on the biology of Philippine mosquitoes. II. Observation on the life and behavior of Aedes albopictus (Skuse) in the laboratory”, Philippine J. Sci. Vol. 92, pp. 89-103(1963).Devonshire, A. L. and L. M. Field., “Gene amplification and insecticide resistance”, Ann. Rev. Entomol. Vol. 36, pp. 1-23(1991).Estrada-Franco JG, Craig Jr GB. “Biology, disease relationships and control of Aedes albopictus. ” PAHO Technical Paper 2: 483-485 (1995).Feyereisen, R., “Molecular biology of insecticide resistance,” Toxicol. Lett., Vol. 82-83, pp. 83-90 (1995).Georghiou, G. P. and N. Pasteur., “Organophosphate resistance and esterase patterns in a natural population of the Southern house mosquito from California”, J. Econo. Entomol. Vol. 73, pp. 489-492(1980).Gibbons, R.V., and Vaughn, D.W.,“Dengue: an escalating problem,” BMJ., Vol. 324, pp.1563-1566 (2002).Gubler, D. J. Dengu, pp. 223-260. In T. P. Monath (ed.), The arboviruses: epidemiology and ecology., Vol. 2. CRC, Boca Raton, FL(1988).Gubler, D. J., and G. Kuno, “Dengue and dengue hemorrhagic fever”, Cab International. pp. 1-18(1997).Gubler D. J., “Dengue and Dengue Hemorrhagic Fever”, Clinical Microbiology Reviews, Vol. 11, pp. 480-496(1998).Guzman, M. G., and Kouri, G., “Dengue: an update. Lancet Infect Dis”, Vol. 2, pp. 33-42(2002).Guzman, M. G., Halstead, S. B., Artsob, H., Buchy, P., Farrar, J., Gubler, D., J., Hunsperger, E., Kroeger, A., Margolis, H. S., Martínez, E., Nathan, M. B., Pelegrino, J. L., Simmons, C., Yoksan, S., and Peeling, R. W., “Dengue: a continuing global threat,” Nat.Rev. Microbiol. , (2010).Habig, W.H., Pabst, M.J., and Jakoby, W.B., “Glutathione S-transferases. The first enzymatic step in mercapturic acid formation, ” J. Biol Chem., Vol. 249, No. 22, pp. 7130-7139 (1974).Harada, K. I., Suomalainen, M., Uchida, H., Masui, H., Ohmura, K., Kiviranta, J., Niku-Paavola, M. L., and Ikemoto, T., “Insecticidal Compounds Against Mosquito Larvae from Oscillatoria agardhii Strain 27”, Enviro Toxicol Vol. 15, pp.114-119(2000).Hawley, W. A., “The biology of Aedes albopictus”, J. Am. Mosq. Control Assoc. Vol. 4, pp. 1-40(1988).Hemingway, J., “The biochemical nature of malathion resistance in Anopheles stephensi from Pakistan”, Pestic. Biochem. Physiol, Vol.17, pp. 149-155(1982).Hemingway, J., Hawkes, N., and McCarroll, L.,“The molecular basis of insecticide resistance in mosquitoes, ” Insect Biochem Mol Biol.,Vol. 34, pp. 653-665 (2004).Hertlein MB,Mavrotas C, Jousseaume C, Lysandrou M, Thompson GD,Jany W, et al, “ A review of spinosad as a natural mosquito product for larval mosquito control. ” J AmerMosq Contr Assoc 26:67–87 (2010).Hsieh, W. C., M. F. Chen, K. T. Lin, S. T. Hsu, C. I. Ma, and S. S. Wu. “ Study of outbreak of dengue fever on Liouchyou Shiang, Pingtung County in 1981”, J. Formosan Med. Ass. Vol. 81, pp. 1388-1395(1982).Kao, L. R., N. Motoyama, and Dauterman,W. C.,“Studies on hydrolases in various house fly strains and their role in malathion resistance, ” Pestic. Biochem. Physiol., Vol. 22, pp. 86-92 (1984).Kroeger A, Nathan M, Hombach J., “World Health Organization TDR Reference Group on Dengue”, Dengue. Nat. Rev. Microbiol. Vol. 2, pp. 360-361(2004).Lien, J. C., P. Y. Hsieh. and H. M. Lin., “On Aedes aegypti and Aedes albopictus in Taiwan”. NAMRV-2 Symposium Taipei(1966).Lien, J. C., Y. C. Wu., H. M. Hwang., C. L. Chung., T. Y. Yueh and L. C. Lu., “Survey and control of dengue fever vectors Aedes aegypti and Aedes albopictus, in Taiwan during 1987 – 1992”, Dengue—A worldwide problem, a common strategy. Proceeding International Conference dengue and Aedes aegypti community based control. pp. 185 -195(1992).Lima, E. P., Paiva, M. H. S., Araújo, A. P., Silva, E. V. G., Silva, U. M., Oliveira, L. N., Santana, A. E. G., Barbosa, C. N., Neto, C. C. P, Goulart, M. O. F, Wilding, C. S., Ayres, C. F. J., and Santos M. A. M., “Insecticide resistance in Aedes aegypti populations from Ceará, Brazil, ” Parasit. Vectors, Vol. 4, No. 5, pp.1-12 (2011).Liu, J. W., Khor, B. S., Lee, C. H., Lee, I. K., Chen, R. F., and Yang, K. D.,“Dengue haemorrhagic fever in Taiwan, ” Dengue Bulletin, Vol. 27, pp. 19-23 (2003).Liu, Z. W., Y. J. Zhang, and Y. Z. Yang. “ Population dynamics of Aedes (Stegomyia) albopictus (Skuse) under laboratory conditions. Acta Entomol. Sinica Vol. 28, pp. 274-280(1985).Liu J. W., Khor B.S., Lee C.H., Lee I. K., Chen R. F., and Yang K. D., “Dengue haemorrhagic fever in Taiwan”, Dengue Bulletin, Vol. 27, pp. 19-23(2003)Liu, H., Cupp, E. W., Guo AiGuang, Liu, N. N. “Insecticide Resistance in Alabama and Florida Mosquito Strains of Aedes albopictus”. J. Med. Entomol. Vol. 41, pp. 946-952(2004).Macdonald, W. W., “Aedes aegypti in Malaya. I. Distribution and dispersal”, Ann. Trap. Med. Parasitol, Vol. 50, pp. 385-398(1956).Marcombe, S., Darriet, F., Agnew, P., Etienne, M., Yp-Tcha, M-M., Yébakima, A., and Corbel, V.,“Field Efficacy of New Larvicide Products for Control of Multi-Resistant Aedes aegypti Populations in Martinique (French West Indies),” Am. J. Trop. Med. Hyg., Vol. 84, No.1, pp.118-126 (2011).Marcombe, S., Mathieu, R. B., Pocquet, N., Riaz, M-A., Poupardin, R., Se´ lior, S., Darriet, F., Reynaud, S., Ye´bakima, A., Corbel, V., David, J-P., and Chandre, F., “Insecticide Resistance in the Dengue Vector Aedes aegypti from Martinique: Distribution, Mechanisms and Relations with Environmental Factors, ” PLoS ONE, Vol.7, No. 2, pp.1-10 (2012).Marcombe, S., Poupardin, R., Darriet, F., Reynaud, S., Bonnet, J., Strode, C., Brengues, C., Yébakima, A., Ranson, H., Corbel, V., and David, J.P., “Exploring the molecular basis of insecticide resistance in the dengue vector Aedes aegypti: a case study in Martinique Island (French West Indies), ” BMC Genomics, Vol. 10, No. 494, pp.1-14 (2009).Metcalf, R. L., “ Insect resistance to insecticides, ” Pestic. Sci., Vol. 26, pp. 333-358 (1989).Nakatsugawa, T., and Morelli, M. A.,“Microsomal oxidation and insecticide metabolism,” Insecticide Biochemistry and Physiology, Plenum Press, New York, pp. 61-114 (1976).Paupy C, Girod R, Salvan M, Rodhain F, Failloux AB, “Population structure of Aedes albopictus from La Reunion Island（Indian Ocean）with respect to susceptibility to a dengue virus”,Heredity.Vol. 87, pp. 273-283(2001).Pérez, C. M., Marina, C. F., Bond, J. G., Rojas, J. C., Valle, J., and Williams, T.,“Spinosad, a naturally derived insecticide, for control of Aedes aegypti (Diptera: Culicidae): efficacy, persistence, and elicited oviposition response, ” J. Med. Entomol., Vol. 44, No. 4, pp. 631-638 (2007).Pimsamarn, S., Sornpeng, W., Akksilp, S., Paeporn, P., and Limpawitthayakul, M.,“Detection of insecticide resistance in Aedes aegypti to organophosphate and synthetic pyrethroid compounds in the north-east of Thailand, ” Bull World Health Orang, Vol. 33, No.21, pp. 194-202 (2009).Ponlawat, A., Scott, J. G., and Harrington, L. C.,“Insecticide susceptibility of Aedes aegypti and Aedes albopictus across Thailand, ” J. Med. Entomol., Vol. 42, No. 5, pp. 821-825 (2005).Rodriguez-Coto, M. M.; Bisset-Lazcano, J. A.; Molina-de-Fernandez, D.; Soca, A., “ Malathion resistance in Aedes aegypti and Culex quinquefasciatus after its use in Aedes aegypti control programs”, J-Am-Mosq-Control-Assoc. Vol. 16, pp. 324-330(2000).Romi R, Toma L, Severini F, Di Luca M., “Susceptibility of Italian populations of Aedes albopictus to temephos and to other insecticides,” Journal of the American mosquito control association, Vol. 19, pp. 419-423(2003).Roush, R. T. and Tabashmk, B. E., “ Pesticide Resistance in Arthropods, ” Chapman and Hall, New York, pp. 4–38 (1990).Rush, A. B., “An account of the bilious remitting fever, as it appeared in Philadelphia in the summer and autumn of the year 1780,” Medical inquiries and observation, Philadelphia: Prichard and Hall, pp.104-117 (1789).Saelim, V., Brogdon,W. G., Rojanapremsuk, J., Suvannadabba, S., Pandii, W., Jones, J. W., and Sithiprasasna, R., “Bottle and biochemical assays on temephos resistance in Aedes aegypti in Thailand, ” Southeast Asian J. Trop. Med. Public Health, Vol. 36, pp. 417-425 ( 2005).Selleena, P., Lee, H. L., and Chiang, Y. F., “Thermal application of Bacillus thuringiensis serovar iraelensis for dengue vector control”, J. Vect. Ecol. Vol. 24, pp. 261-223(2001).Service, M. W., A guide to medical entomology, pp. 53-70, The MacMillan Press LTD., London and Basingstoke(1980).Silva, O. S., Romao, P. R., Blazius, R. D. and Prohiro, J. S., “The use of andiroba Carapa guianensis as larvicide against Aedes albopictus”, J. Am. Mosq. Control Assoc, VOl. 20, pp. 456-457(2004).Soderlund, D. M., and Knipple, D. C.,“ The molecular biology of knockdown resistance to pyrethroid insecticides,” Insect Biochem. Mol. Biol., Vol.33, pp.563-577(2003).Taylor CE. Quaglia F. Georghiou GP. “Evolution of resistance to insecticides:A cage study on the influence of migration and insecticide decay rates. ”J Econ Entomol 76: 704-707 (1983).Thompson GD, Dutton R and Sparks TC, “ Spinosad, a case study: anexample from a natural products discovery programme. ” PestManagSci 56:696–702 (2000).Vaughan, A., Chadee, D., D., and efrench-Constant., R., “Biochemical monitoring of organophosphorus and carbamate insecticide resistance in Aedes aegypti mosquitoes from Trinidad, ” Med. Vet. Entomol., Vol. 12, pp. 318-321(1998).Wang C. H., Chang N. T., Wu H. H., and Ho C. M. “Integrated control of the dengue vector Aedes aegypti in Liu-Chiu village,Pingcounty,Taiwan”, Journal of the American mosquito control association, Vol.16(2), pp. 93-99(2000).Wilkinson, C. F., “ Role of mixed-function oxidases in insecticide resistance”. In Pest Resistance to Pesticides, eds. by G. P. Georghiou and T. Saito, pp. 175-203. Plenum Press, New York(1983).Williams T, Valle J and Vi ˜ nuela E, Is the naturally derived insecticide spinosad compatible with insect natural enemies? Biocontr Sci Technol 13:459–475 (2003).World Health Organization (WHO).“Chemotherapy of malaria and resistance to antimalarials,” Geneva, WHO Technical Report Series, No. 529, pp.1-124 (1973).World Health Organization(WHO).“Dengue and dengue haemorrhagic fever,” (http://www.who.int/mediacentre/factsheets/fs117/en/index.html). Download at 12/30/2013.

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